RELATED: Obama, celebs support Kimmel after son's health scare
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During an emotional and heartfelt monologue, Kimmel explained, "They found that Billy was born with a heart disease."
The late night talk show host took last week off, after telling viewers about his son's open-heart surgery. The family says Billy is doing great.
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On Monday, the "Jimmy Kimmel Live!" team tweeted a sweet photo of Kimmel laughing during rehearsal at the desk, surrounded by mariachi musicians. They wrote, "He doesn't like when we make a fuss, so we did anyway..."
One of Kimmel's guests for Monday night is Louisiana Senator Bill Cassidy.
The republican said a health care bill should pass the "Kimmel test" and cover pre-existing conditions.
Watch "Jimmy Kimmel Live!" weeknights at 11:35 p.m. after ABC7 News at 11 p.m.