The 5K run and walk started at 9 a.m. outside the Ferry Building, where participants ran along the Embarcadero.
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So far this year, the race has raised more than $200,000 for breast cancer research and treatment. The goal is $300,000.
ABC7 News' Kate Larsen emceed the event in San Francisco.
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The Susan G. Komen Race for The Cure is the largest and most successful education and fundraising event for breast cancer.