Students at Burton High School cried and expressed their anxiety over the rise in hate speech since Donald Trump's election.
Students said they felt rejected for being different and feared a rise in deportations.
"I'm not facing anything, but it's like I'm scared for my family and my friends that are immigrants," said Karen Hwang, a student.
"You heard from the kids today, fear and anxiety about their families being deported, about their dreams being destroyed. That's real," Newsom said.
San Francisco's superintendent is sending families a letter to reassure them.
It says the district will protect students against what it describes as "systematic oppression."