The actor's representative said Perry was under observation at the hospital Thursday morning,
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The Los Angeles Fire Department responded to the "Beverly Hills, 90210" actor's home in Sherman Oaks Wednesday shortly before 9:40 a.m. regarding a request for medical aid.
According to dispatch audio, the medical aid call was in response to a stroke patient.
The 52-year-old was transported by an ambulance to a local hospital. His publicist said reports that the actor is in a coma are not true.
Perry shot to fame for his role as Dylan McKay on the hit TV show "90210," which ran from 1990 to 2000. He currently stars on the show, "Riverdale."
Molly Ringwald, who plays Perry's wife on "Riverdale," tweeted about her co-star.
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Former co-stars Shannen Doherty and Ian Ziering also showed support.
"My friend. Holding you tight and giving you my strength. You got this," Doherty said in an Instagram post.
"No words can express what my heart feels hearing today's shocking news. Let us all say a prayer for his speedy recovery," Ziering said.
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Perry has had roles in a handful of films, including "The Fifth Element," ''8 Seconds" and "American Strays." He appeared in HBO's prison drama "Oz" and voiced cartoons like "The Incredible Hulk" and "Mortal Kombat." In recent years he starred in the series "Ties That Bind" and "Body of Proof."
'Beverly Hills 90210' star Luke Perry hospitalized
Doctors say people even younger than Perry can suffer a stroke.
Nearly 800,000 Americans suffer strokes every year. It's the leading cause of disability and death.
Recognize the signs of stroke using "F.A.S.T.":
-Face: Smile and see if one side of the face droops.
-Arms: Raise both arms. Does one arm drop down?
-Speech: Say a short phrase and check for slurred or strange speech.
-Time: If you answer yes to any of these, call 911 right away.
The Associated Press contributed to this report.