It's not the first time the 23-year-old "Hope for the World Cure" mural has been targeted, but it's definitely the most severe.
[Ads /]
The damage is expected to cost $50,000 to repair and restore, putting the future of the mural in jeopardy.
RELATED: 'This needs to stop': Vandalism at Manny's in SF part of nationwide rise in anti-Semitic incidents
It was originally funded by a grant from the San Francisco Arts Commission.
[Ads /]