The crash happened just after 9:30 p.m. in the 7800 block of International Boulevard.
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Officers were sent to the area and located 17-year-old Alejandro Herrera Miranda and 26-year-old Leroy Rodrigues with severe injuries, according to police and the coroner's bureau.
Firefighters and paramedics also responded to treat the pair. Both died at the scene, police said.
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Three vehicles were involved in the crash and police detained one of the drivers. Police said they don't yet know if alcohol or drugs played a role in the tragedy.
Police are investigating the crash and anyone with information about it can call the department's traffic investigation unit at (510) 777-8570.