The shooting happened just before noon at 1st Avenue and East 12th Street.
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The victim was found inside a vehicle in the parking lot of the Americas Best Value Inn hotel.
It appears the car crashed in the parking lot, and the shooting happened at another location.
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The victim's identity is being withheld pending notification to next of kin.
Anyone with information is asked to contact the Homicide Section at (510) 238-3821 or the TIP LINE at (510) 238-7950.