Crews responded to reports of the fire at 524 Moraga Way just before 4:00 a.m.
When they arrived, the home was engulfed in flames.
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Nine engines responded to the scene and had the fire under control just after 5:00 a.m.
The teenage girl did not survive.
Officials say two other people and a firefighter suffered burn injuries and were taken to hospitals.
The firefighter was treated and released. There is no update yet on the status of the others.
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Moraga Way between Ivy Dr. and Coral Dr. was closed for several hours.
The cause of the fire is under investigation.