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The California Highway Patrol says that the crash happened on 101 before Hellyer Ave.
The box truck was carrying 130 gallons of fuel and is now on its side, according to CHP.
The San Jose hazmat team is responding to the crash for the diesel spill.
A metering light was also hit and there is broken concrete and exposed wire.
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Lanes were blocked for several hours as crews responded.
Stay with ABC7 News for updates on this developing story.