The driver of a Nissan Altima driving southbound on Interstate 680 near Monument Boulevard swerved to avoid some debris and crashed into a Chevrolet Volt around 8:30 p.m., CHP spokesman Officer Brandon Correia said.
The Volt then crashed into a Volkswagen Jetta, Correia said.
"When the vehicles came to a stop, the Altima burst into flames," the spokesman said.
Two passengers in the back seat of the Altima suffered burns and were taken to the Bothin Burn Center at St. Francis Memorial Hospital in San Francisco, Correia said.
All three vehicles were damaged, but the damage was not major, he said.
All lanes of the highway were shut down for around a half-hour after the crash, according to Correia.