CHP says at around 10:40 p.m. officers were chasing a silver sedan westbound on the Bay Bridge when it exited on 9th Street.
The car then crashed into two other cars, including a Waymo carrying passengers at the intersection of Folsom and 11th streets.
VIDEO: Man accused of throwing bombs at police during SF car chase appears in court
Man accused of throwing bombs during SF car chase appears in court
During the crash, the suspect's car went onto the sidewalk and hit two pedestrians. Both pedestrians were transported to the hospital, one with major injuries and the other with minor injuries.
The driver in the pursuit was also injured and taken to the hospital.
A passenger in one of the cars that was hit was injured but declined going to the hospital.
Officers say the Waymo was carrying passengers but no one in that car was hurt.
CHP says they are investigating if the pursuit suspect hit other drivers before getting off the freeway.