The suspect's vehicle collided with a pole and the patrol car crashed into a building near San Bruno Ave and Paul Ave around 3:20 a.m.
Two officers were hurt but are expected to be OK.
SFPD says the chase happened after a traffic stop when officers spotted a driver who evaded police the day before and was currently driving recklessly.
Two suspects were also injured in the crash and were arrested after trying to run away after the crash. Officers also found a gun at the scene.