The crash was reported around 3 p.m. and happened on westbound State Route 37, west of Walnut Ave. in Vallejo.
CHP Solano says the roadway is open, but will eventually close to begin a hazmat cleanup as a large quantity of gasoline is leaking into the water.
Eastbound and westbound directions of State Route 37 will be closed from State Route 121 to Walnut Avenue.
Authorities say the closure could last between 6 to 8 hours.
Drivers are asked to avoid the area and take alternate routes.
You can monitor Bay Area traffic conditions here.