The church is at Borderick and California in the Lower Pacific Heights area.
Crews working to put out 2-alarm fire at San Francisco church: SFFD
SFFD says over 100 firefighters are deployed to put out the flames.
Video posted on social media by the San Francisco Fire Department shows smoke coming out of the church and that there is scaffolding around part of the building.
There is a power outage in the area, according to the PG&E outage map.
Fire officials say it's a multistory church and no injuries have been reported.
They are asking people to avoid the area and for people to shelter in place if they are in the 2800 Block of California St. due to the smoke.
Stay with ABC7 News for updates on this developing story.