The pursuit started just before 8 p.m. about a mile south of Lake Merritt.
Oakland police say during the CHP chase, the driver hit another car at Park Boulevard and East 21st Street, leaving one person with minor to moderate injuries.
Police say the CHP then called off the pursuit, and the driver kept going.
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It all ended on 12th Street, where the driver ran over two pedestrians.
One died and the other is in the hospital.
Oakland police say they're now investigating the deadly crash.