The first report of the collision on I-880 just north of Davis Street came in at 3:02 a.m.
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CHP officials issued a Sig-alert at 3:26 a.m. and canceled the alert at 5:13 a.m.
Up to seven vehicles were involved in the collision, according to the CHP. One person is in critical condition and another has moderate injuries, according to the Alameda County Fire Department. Three people declined transportation for medical treatment, the Alameda County Fire Department tweeted.