The fire began at 11:08 p.m. and burned the third floor of a residential unit.
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Residents in the immediate area witnessed large flames and said the smoke was pretty thick.
According to Mission Local, 628 Shotwell Street is a senior care facility where six residents all out safely. The assisted living home is called the Lorne House. Several people in a nearby building were also displaced.
One person was treated for smoke inhalation and there are no other injuries. The cause of the fire is under investigation.