The restaurant has been open on 4th Street in Jack London Square since 2004.
The owner says it's time to move on.
"It will be a little sad, but I'm ready for the next chapter in life. I am very appreciative to the people in Oakland. Everyone that's helped build the business. I mean, look at this. This is great," said Derreck Johson, owner of Home of Chicken and Waffles.
The restaurant became a community gathering place and drew some well-known customers, including former Secretary of State Hillary Clinton and former Vice President Kamala Harris.