The collision happened at about 12:30 a.m. on Highway 25 near Bloomfield Avenue.
The California Highway Patrol said a 24-year-old man driving a 2018 Nissan Sentra was headed south on the road near Bloomfield Avenue when he swerved over double yellow lines into the northbound lane.
The Nissan ran into an oncoming vehicle, a 2012 Dodge Charger being driven by a Santa Clara County 911 communications dispatcher.
That dispatcher has been identified as 35-year-old Priscilla Jones.
The road was closed for five hours for investigation.
It's not known if drugs or alcohol factored in the collision.
Bay City News contributed to this report