The crash was reported at 6:01 a.m. on the highway near the connector to state Highway 92 and the San Mateo-Hayward Bridge.
The motorcyclist died in the crash. More information about the victim were not immediately available this morning, CHP officials said.
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The crash blocked lanes of the highway for more than two hours. All lanes reopened as of shortly before 8:40 a.m., according to the CHP.
The cause of the crash remains under investigation.