The sheriff's department says it happened at the San Marco Boulevard exit near Bay Point. The shooting was on city streets close to Willow Pass Road.
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The CHP said traffic on Highway 4 was backed up due to the shooting.
Claycord.com reported the shots came from a silver vehicle with a broken window. Investigators have not said if anyone has been hit.
On Saturday, one person was shot and killed on Highway 4 near San Marco Boulevard in Bay Point. A 20-year-old man was killed and investigators have not made any arrests in that case.
VIDEO: Pittsburg father killed in drive-by on Highway 4 mourned by coworkers