It happened at 175 W. 13th Street around 7 p.m.
The water is flooding the streets and the subway tunnel.
Some 500 people had to be removed from a subway train underground.
The Fire Department has requested DEP emergency crews and Con Ed Gas to the scene.
Due to the water main break, there is no 1 train service between South Ferry and Times Square-42 St.
There is no northbound 2 and 3 train service between Chambers St and Times Square-42 St in both directions.
2 trains are running on the 5 line from Nevins St to 149 St-Grand Concourse.
1, 2 and 3 trains are running with delays in both directions.
The MTA says that they hope to have service up and running again for the Thursday morning commute.