East Bay Municipal Utility District got the call at 5:20 a.m. about the water main break on 45th St. and Carlson.
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Streets are flooded and the fire department is on scene as crews work to shut off the water.
EBMUD says they believe the problem is a 12-inch cast iron pipe.
EBMUD will determine how long it will take to fix and how many customers will be without water while repairs are being made.
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Stay with ABC7 News for updates on this developing story.