It happened around 3 p.m. just north of Sam's Chowder House.
The CHP says the Ford driver was air lifted to Stanford.
"Ford's elderly female driver and juvenile passenger transported to Stanford. Unknown injuries to driver, juvenile sustained major injuries," CHP said on Twitter.
The cement truck driver was taken to SF General with unknown injuries at this time, officials said.
Highway 1 was closed in both directions at Capistrano and reopened around 3:50 p.m
Stay with ABC7 News for the latest details on this developing story.