75-year-old Sacheen Littlefeather famously turned down Marlon Brando's Best Actor Academy Award in 1973.
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Brando boycotted the award ceremony in protest of the portrayal of Native Americans in films.
In August, the Academy issued an apology for the mistreatment Littlefeather received because of that incident.
People who knew her say her contributions were significant.
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"She was a person who made a huge sacrifice for our community as far as representation visually in Hollywood, and so the community is forever indebted to her for her bravery, for her courage and for her willingness to reject that Oscar," said Manny Lieras, Littlefeather's friend.
Littlefeather's activism began when she became part of the Native American occupation of Alcatraz Island in 1969.