The death happened last week, the San Francisco Department of Public Health said in a news release. The person was under 65, was not vaccinated and had preexisting medical conditions.
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Health officials are urging residents to get vaccinated, if they haven't already done so, against the flu, COVID-19 and respiratory syncytial virus (RSV).
MORE: How to avoid the 'tripledemic' of RSV, COVID-19, flu
"These viruses pose the greatest risk to infants, older adults, and persons with certain health conditions," the health department said in a news release. "Getting recommended vaccines when pregnant protects pregnant people as well as their babies."
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Flu, COVID-19, and RSV vaccines can be given at the same time.
The department recommends that everyone 6 months and older should get annual flu vaccine. Children 8 years and younger need two doses the first year they get the flu vaccine, officials said.