The incident happened at N. Autumn Street and Julian Street.
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When officers arrived on scene, they located a man in the middle of the intersection, suffering from multiple stab wounds.
Police say they spotted the suspect who was on scene and armed with a knife. The suspect did not comply with officers' commands to drop the knife.
The suspect reportedly advanced on the officers, and discharged their firearms in response.
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Body cameras were used.
The officers were not injured.
The Santa Clara County District Attorney's Office and the San Jose Police Department's Homicide Unit are conducting a joint criminal investigation.
San Jose Police Chief Eddie Garcia will speak at a press conference on Monday, May 4 at 1pm.