The incident started around 1:30 p.m. when police responded to a call reporting a naked man acting erratically in the street at Valerie Drive and Eva Court, near San Tomas Park, San Jose police Sgt. Enrique Garcia said.
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The man was also involved in at least one crash with a citizen during the pursuit, Garcia said.
At least two officers then fired about a dozen shots at the man, according to United Towing employee James Shaw, who said he witnessed the shooting from across the street.
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"Our officers attempted to make the car stop and take the suspect into custody. During that encounter multi-officers fired at the suspect. He was struck at least once. The suspect was taken into custody and transported to a local hospital and he is listed with life-threatening injuries," said Garcia.
Stevens Creek Boulevard was shut down for the investigation. No officers were injured during the incident.
Bay City News contributed to this report