The crash was reported after 7:45 a.m. and caused the CHP to divert traffic off southbound Highway 101 to Highway 880.
Around 9 a.m., the California Highway Patrol started righting the big rig, moving it to the shoulder and allowing traffic to get moving again. All lanes of Highway 101 were fully reopened around 10:40 a.m.
A Sig Alert was issued for the area, meaning traffic was being significantly disrupted, but has since been lifted.