The crash between a car and the cyclist was reported around 5 p.m. when the CHP responded to the accident on Cañada Road near Filoli Garden.
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Authorities say the sedan was driving in the northbound direction on Cañada Road and crashed with the cyclist who was also traveling northbound on Cañada Road.
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The CHP says the cyclist, a 37-year-old man from South San Francisco, suffered major injuries and was pronounced dead at the scene. The victim's name has not been released.
The CHP says it's unknown what caused the two vehicles to crash.
The driver, from Redwood City, and the passenger were taken to hospital as a precautionary measure.
Witnesses are asked to contact the Redwood City Area Office at 650-779-2700 with any information regarding this crash.