Officials say a suspect killed a man around 7:20 a.m. in the 1700 block of Pierce Street and minutes after the homicide, officers located the suspect in his residence in the 1600 block of Marina Court.
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San Mateo police, the North Central Regional SWAT Team and the Crisis Negotiation team immediately began negotiations with the suspect.
After nearly four hours, officials say the suspect refused to surrender and died by suicide inside his home around noon.
Officers learned the suspect's wife was inside the home with him and was unharmed.
The investigation is ongoing and the reason for the homicide is still unknown.
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Officials say additional information will be made available as this investigation develops.
Anyone with information or security footage related to this homicide is encouraged to contact Detective Sergeant Lee Violett at (650) 522-7662 or lviolett@cityofsanmateo.org. Anonymous tips can be submitted to http://tinyurl.com/SMPDTips or by calling (650) 522-7676.
Stay with ABC7 News for this developing story.