Police say officers responded to the crash at 9th Avenue and Lincoln Way around 6 p.m.
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When officers arrived on scene they found three people suffering from life-threatening injuries and all were taken to the hospital.
An initial investigation determined one of the cars smashed into the back of another causing the vehicle to collide with the bus stop where those three people were waiting.
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Anyone with information is asked to contact the SFPD at 415-575-4444 or text a tip to TIP411 and start the message with SFPD.