It happened just around 3:00 a.m. Sunday morning at Cesar Chavez and Vermont Street, right under the Bayshore Freeway.
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The person who is injured is expected to be okay.
Police are investigating the cause of the accident.
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Further details are not available at this time.
SFPD investigates cause of fatal crash in Potrero Hill
Stay with ABC7 News for the latest details on this developing story.