Police responded to the residence on Navy Rd. at 7:37 a.m. and met with two parents who directed them to the children. The found a 1-year-old girl and a 5-year-old girl, both unresponsive.
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The children were declared dead on the scene.
After investigating, police arrested 34-year-old Paulesha Green of San Francisco.
It's unclear what her connection is to the victims.
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Green is being held in the San Francisco County Jail on two counts of homicide.
Anyone with information is asked to call the SFPD Tip Line at 1-415-575-4444 or Text a Tip to TIP411 and begin the text message with SFPD. You may remain anonymous.