The crash happened on Geary between 3rd Avenue and Arguello.
It happened at about 8:30 a.m. Saturday. Police say three officers and a civilian were taken to the hospital. Their conditions are not known.
Right now there is no word on what caused the accident.
The scene was cleared and the road reopened around 2:00 p.m.
Stay with ABC7 News for the latest on this developing story.