The shooting happened at 1 p.m. on I-280 southbound, according to police.
CHP says a "solo female driver" sustained one gunshot wound to the lower leg and was taken to a local hospital.
Her full condition is not known at this time.
After the shooting occurred, police say the victim pulled over on Monterey Avenue.
This is still an active investigation.
CHP is asking the public for any eyewitnesses to reach out to local law enforcement.
Stay with ABC7 News for the latest details on this developing story.