Isidoro Pena-Silva was last spotted at about 11:30 p.m. on Thursday.
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Pena-Silva suffers from a medical condition and may be disoriented, according to the CHP.
He is described as being 5 feet 7 inches tall, 240 pounds, with gray hair and brown eyes.
Pena-Silva is believed to be wearing a black jacket, jeans and white sneakers.
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Anyone with information on his whereabouts is urged to call 911.