Fresno Fire says a windshield on the plane, operated by SkyWest, broke near Mono Lake, causing a loss of cabin pressure.
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According to data on the flight-tracking website FlightAware, American Airlines flight 3130 made a quick but controlled descent from 36,000 feet down to 20,000 feet.
Fire officials confirmed that no one was injured.
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Stay with ABC7 News for the latest details on this developing story.