Police say the 90s Toyota Camry was going the wrong way in the eastbound lanes of El Camino Real when the driver lost control of the car at around 4:45 Friday morning.
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The vehicle went over the center median, launched into the eastbound lanes and crashed over a small wall in front of The Mission Inn on the corner of El Camino Real and Alviso Street.
Two shipping containers being used as storage for nearby construction crews stopped the Camry from going any farther.
"Alcohol could be definitely a factor in this. Speed is obviously a factor in this, just given the trajectory and path of travel for the vehicle," said Santa Clara Police Captain Wahid Kazem.
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The driver died at the scene. Police don't believe there's another person inside but will have to wait for the vehicle to be removed to know for sure.
The shipping containers will likely have to be moved to remove the Camry.
The police investigation has shut down the westbound lanes of El Camino from Harrison Street and De La Cruz Boulevard.