Fire Commissioner Daniel Nigro says the fire broke out after 5:30 p.m. Saturday in an apartment on the 50th floor of the midtown skyscraper.
Nigro says four firefighters suffered less serious injuries.
President Donald Trump tweeted that the fire was out and said it was "Very confined (well built building)."
Trump's business is based at Trump Tower and his residence is there, but he has spent little time in New York since taking office.
Nigro says no member of the Trump family was at the building on Saturday.