Arson investigators are at the home as protocol, however Oakland fire Lt. David Brue said the blaze does not appear to be suspicious.
The fire was reported at 1:39 a.m. and fire crews arrived at the single-family home at 2640 74th Ave. within minutes, said Brue. The east Oakland residence was fully involved in flames upon the arrival of firefighters.
A second alarm was called at 1:44 a.m.
Firefighters conducted a primary search of the home and found two victims in the rear of the residence, Brue said. Both men, ages 47 and 57, were pronounced dead at the scene.
Five other occupants of the home were able to escape the flames and have been displaced, according to Brue. The relationship of the home's occupants was not immediately available.
Fire officials have not yet determined monetary damage inflicted by the blaze, however the home sustained significant damage.
"It's not burned to the ground but there's major, major damage," said Brue.
Two adjacent homes sustained some heat damage from the flames, Brue said.