The fire was reported in an apartment building at 2241 E. Leland Road at 7:34 p.m.
Firefighters responding to the call saw smoke from half a mile away and immediately called for a second alarm, Hopkins said.
When they arrived, smoke and flames were coming out of the northwest corner of the building on both floors.
A total of 14 engines, manned by about 50 firefighters, knocked the main body of the fire down by 8:18 p.m., but the damage caused the roof to collapse, Hopkins said.
The blaze was extinguished by 8:42 p.m.
Some people were treated at the scene for smoke inhalation, but nobody was taken to the hospital, Hopkins said.
The American Red Cross is helping the displaced family. There was no word about the building's other occupants.