The fire was reported at about 7:50 p.m. in a residence at 2810 Hosmer St. and was declared under control at 8:32 p.m.
Novelli said at least 60 percent of the home was involved in the blaze when firefighters arrived, and that damage to the home and its contents will be between $350,000 and $500,000.
The fire also caused minor damage to the house next door, but firefighters were able to quickly knock down the blaze, Novelli said.
Between 35 and 45 firefighters assisted at the scene of the fire, according to Novelli, who said an engine would remain at the home overnight to guard against any flare-ups.
No injuries were reported and the cause of the fire is under investigation, he said.
The resident of the home works for the city of San Mateo and knows a lot of firefighters, according to Novelli, who said the incident "certainly hits home for us."