Officers from Vacaville and Fairfield police narcotics teams served a warrant at a home at 1322 Coolidge St. at around 4:10 p.m., according to the Vacaville Police Department.
A search of the residence allegedly yielded drugs, drug paraphernalia and evidence of methamphetamine sales.
Christopher Poujade, 42, the homeowner, was arrested for maintaining a drug house and violation of probation, according to police.
Fairfield resident Pamela Welch, 56, and Gary Severa, 43, of Vacaville, were both arrested for methamphetamine possession.
Levitta Velasquez-Jandreau, 28, also of Vacaville, was arrested for possession of meth and a hypodermic syringe.
Another suspect and wanted parolee, Gary Horton, reportedly fled the residence and avoided a police search. The four suspects taken into custody were booked into Solano County Jail in Fairfield, police reported.
Anyone with information regarding this or other drug activity in Vacaville neighborhoods is asked to contact the Police Department's drug tip line at (707) 449-5243. Callers may remain anonymous.