The district recently confirmed that mosquitoes in Sunnyvale tested positive for West Nile after a bird was found to be infected with the virus about a mile away on May 26.
The fogging is scheduled to start at 11 p.m. and will last for several hours.
The fogging area is bordered by state Highway 237 on the north, Fair Oaks Avenue on the west, Great America Parkway in Santa Clara on the east, and East Arques Avenue on the south, according to the district.
Information packets are being distributed in the fogging area today to notify residents about the operation.
A community informational open house meeting has also been scheduled for Tuesday at 6:30 p.m. in the multi-purpose room of Lakwood Park at 750 Lakechime Drive in Sunnyvale.
Transmitted by mosquito bites, West Nile virus causes flu-like symptoms such as fever, headache, body ache, and in severe cases, significant neurological symptoms or even death. The elderly and those with weak immune systems are most at risk.
During 2008, California reported 445 human infections of the virus, including 15 deaths, according to the district.