Pet Airways flies dogs and cats to and from New York, Baltimore, Chicago, Denver and Los Angeles.
Tickets start at $149 dollars and pets get a walk and bathroom break before boarding.
A couple decided to start the airline after getting stressed out while flying their aging jack russel terrier in the cargo bay of an airline.
On Pet Airways, the animals ride in a lit cabin.
Veterinary technicians are also on board to monitor the animals in flight.
Flights are already booked for the next two months.