They held a preview of Saturday's give-away at Bryant Elementary School in the city's Mission District on Friday. Office Depot donated 3,000 back-packs.
They will also include information on how to prevent catching or spreading the flu. It's all in response to predictions of a huge increase in the H1N1 virus cases this winter.
"At the front of every classroom this year, there will be an alcohol-based sanitizer. Do I have any student demonstrators? Let's see show how easy it is to rub that into your hands," says San Francisco's Public Health Department Director Mitch Katz, M.D. to a crowd of school children.
San Francisco city officials say when the vaccine is released every school child will have access to it for free.