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The fire was reported at about 10:50 a.m. at 1526 Wallace Ave., and spread to at least two other buildings in the 1500 block of the street, according to Williams.
Marijuana was found growing in one of the buildings, and Williams said the Police Department's narcotics unit is investigating whether it is an illegal grow operation.
The blaze was still burning at about 4:20 p.m. and Williams did not know when crews expected to have the fire under control.
The cause of the fire is under investigation, he said.
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