The call came in at about 10:30 a.m. from the State Building at 350 McAllister St. The CHP oversees security at the building.
The suitcase was spotted near an elevator in the building's secured underground garage, CHP Officer Shawn Chase said.
A San Francisco sheriff's bomb-sniffing dog inspected the suitcase and the Police Department's bomb squad then X-rayed it and determined it was empty, Chase said.
No evacuations were ordered and the bomb squad left the scene by 12:15 p.m. The owner of the suitcase has not been located, Chase said.