The puppies left San Francisco airport this morning for the cross-country flight. This is the second year San Francisco Animal Care and Control and Virgin America teamed up for the "Operation Chihuahua" airlift.
Animal control says there is an overwhelming number of Chihuahuas.
"They're just really over bred and people aren't spaying and neutering them as much as we would like them. They've become really popular after all the Hollywood hype. People think they're a lot easier than big dogs, but they're still dogs," said Rebecca Katz of S.F. Animal Care and Control.
If you want to adopt one of these cute pups, there are many Chihuahuas at the San Francisco Animal Care and Control waiting to be adopted.